Brain disorders have been linked with heavy metal toxicity such as lead toxicity. Solanum lycopersicum has been reported to be useful in  the treatment of brain disorders. However, there are few reports on it's effect on neurotoxicity induced by lead acetate in rats. . This study was designed to investigate the effect of ethyl acetate extract of Solanum lycopersicum (EESL) on neurotoxicity and oxidative stress induced in male wistar rats