The study was carried out to investigate the effect of aqueous and petroleum ether extract of momordica charantia on blood glucose level of albino rats.The extraction was done using petroleum ether and water .Thirty two albino rats were grouped into eight (A ,B,C,D,E,F,G,H). Comprising of four in each group .Diabetes was induced with a single Dose of 100mg/kg body weight of alloxan solution .After induction of alloxan ,group A and B were orally administered with 100 and 200mg/kg body weight of aqueous momordica charantia extract respectively .group C,D and E were administered with 100 ,200,300mg /kg body weight of petroleum ether extract of momordica charantia ,group F received 70mg/kg body weight of Glibenclamide ,group G received distilled water and feed and was not induced and was not induced alloxan while group H was induced with Alloxan but not treated with the extract nor synthetic drug.The glucose concentration of all the groups treated with alloxan  was significantly higher  than the untreated one. After treatment the Momordica charantia showed the antihypergylcermic effect on the blood glucose concentration compared to those with glibenaclamide.  

Keywords:    Diabetes    mellitus,   Alloxan    monohydrate,   Glibenclamide,   Momordica charantia.