ABSTRACT

This study examined the nephrotic effect of Buchholzia coriacea formulated diet in sucrose-fed pregnant rats and their offspring. Buchholzia coriacea (B. coriacea) (family, capparidaceae) is a perennial plant commonly known as wonderful kola. Seeds were obtained from ogbete main market, Enugu state, identified, dried and grounded using a miller machine. 10% of the seed powder was used to formulate their diet. Thirty (240) adult female and six (6) adult male albino rats (180-250 g) were used in this study. High sucrose (20%) were given via drinking water to animals before, during and after pregnancy. Group A; Control normal was administered distilled water,  Group B received sucrose + 10% Buchholzia Coriacea formulated diet (BCFD), Group C; untreated rats were administered sucrose and distilled water while Group D received 10% Buchholzia Coriacea formulated diet (BCFD) only. All animals were sacrificed following overnight fast by anaesthetic dos e of diethyl ether and cervical dislocation. Blood samples were obtained through cardiac puncture for the analysis of biochemical parameters. Results were represented as mean ± standard error of mean. SUC (20%) (untreated) significantly elevated urea levels (p