Abstract: Self-medication, as one element of self-care, is the selection and use of medicines by individuals to treat self-recognized illnesses or symptoms. It is use of non-prescription medicines by people on the basis of their own initiatives. Although, over the counter drugs are meant for self-medication and are of proven efficacy and safety, their improper use could have serious implications both on health care professionals and their patients or clients. Social work is one of the caring professions which involve promoting and protecting the welfare of individuals and the wider community. Since, health care professionals are also segments of the community they can also be potential candidates for social work intervention. Method: This study aimed to assess self-medication practice among senior medical students of Kampala International University teaching Hospital. Facility based cross-sectional study was conducted among senior medical students selected using stratified random sampling technique. Sample size was calculated to be 294. Data was collected and entered in to Epi-info version 3.6 and analyzed using SPSS version 20. Descriptive statistics was employed. Statistical significance was declared at p-value