This project discusses the influence of genomic structure on phenotypic expression in plants and animals, emphasizing intraspecific variations arising from diverse genomic structures. It highlights historical misinterpretations of structural rearrangements and advocates for comprehensive whole chromosome comparisons. The project focuses on using the SyRI tool to validate findings from whole-genome analysis of sugar beet and sea beet genomes, revealing insights into the role of the Rz2 locus in rhizomania resistance.