This project titled Bioaccumulation of persistent pollutants in Clarias gariepinus gotten from Ogu Creek is based on ecotoxicology and utilized African catfish (Clarias gariepinus) as a model in estimating the bioaccumulation of pollutants in living tissues of organisms in Ogu creek which is a point of poorly treated effluent discharge. The persistent pollutants include Zn, Cr, Cd, Pb, Mn, and Total Petroleum Hydrocarbon (TPH). The concentrations of the heavy metals were determined with Atomic Absorption Spectrophotometer while that of hydrocarbons were measured with TSQ XLS gas chromatography triple quadrupole mass spectrometer system. The Student t-test was used to compare concentrations between the impacted and upstream locations. The one-way analysis of variance (ANOVA) Test revealed that there was a significant difference in the accumulation of Cr (Sig F=0.028) between the muscles and other tissues at p