This work is designed to examine the problem of academic stress among students of the University of Cape Coast, School of Business, its causes and ways of controlling it to enhance the students’ performance. The objective of this study is to examine the effect of stress on the academic performance of University of Cape Coast, School of Business students and the associated risk when stress is not managed properly. To achieve this objective, three (3) research questions were tested and the literature review was mainly focused on the causes, effects and ways of managing academic stress. The instrument of data collection was questionnaire while convenience sampling method and random sampling technique were adopted for the study. Data collected and analyzed were driven from the three (3) research questions posed. A sample size of 100 from a population of over one-thousand (1,000) was used due to the COVID-19 pandemic. From the findings, it was discovered that academic stress could be controlled to enhance students’ performance. The study discovered that by educating students on how to manage stress, staying focus, having enough rest, exercising a lot and effective time management can help to manage stress in order to enhance students’ academic performance.