The study detennines the impact of design and implementation of a centralized dmg distribution in Busia district . the purpose of the study is to design dmg distribution inf01mation system for managing dmgs in Busia district. The study intended to establish and recommend strategies polices to reduce the safety of dmgs for the district this in view of the fact that safty of dmgs is common along the supply chain management. The study was conducted through a cross sectional survey data was collected in Febmary 2012 using questiom1aire ,interviews and observations techniques from 25 countries randomly selected from accessible population by use of both qualitative. Methods of data collections and presented in tables and figures .the study concludes that safety of dmgs within supply chain management system has lead to many death of the people within the disttict especially pregnant women's .it recommends the best supply of dmgs should be centralized .finally I rec01runend that the study be conducted to determine the alterative remuneration strategies for design and implementation of a centralized dmg distribution infonnation system.