ABSTRACT   

In this study, we evaluated the effect of the total phenol extract of Zanthoxylum zanthoxyloides leaves on oral glucose tolerance, lipid profile, liver function, oxidative stress parameters, and pancreas histopathology in diabetic rats. Diabetes was induced in rats by administration of alloxan monohydrate in a dose of 130 mg/kg b/w. Total phenol content of Z. zanthoxyloides leaves was administered to rats at 100, 200 and 400 mg/kg b/w daily for 15 days. Blood glucose was measured by glucose oxidase method; lipid profile, liver function and oxidative stress parameters were monitored by standard methods and pancreatic histopathology evaluated microscopically. The results showed an increase in blood glucose level of the rats after administration of alloxan monohydrate. Two weeks after treatment with Z. zanthoxyloides, a significant (p