Abstract This is a case control study aimed to measure levels of, Prothombin time (PT), activated partial Thromboplastin time (APTT), platelet count in patients with homozygous sickle cell disease (HbSS), sickle cell trait (HbAS) and normal controls (HbAA). The study period from August to October 2019, in Khartoum State in the Sickle Cell Clinic of Gaffer Ibn Auf Children Specialized Hospital and Al-ribat University hospital. The study population comprises two groups of children in different agegroups and gender. The first group of 50 individuals included are the children who are known to have sickle cell anemia (HbSS 41) and (HbAS 9). The second group of 50 individuals included are normal-healthy (HbAA) as a control group. Venous blood sample was collected into tri sodium citrate (9:1) and centrifuged at 4000 rpm for 10 min to obtain plts poor plasma for coagulation study. PT and APTT were measured using (DIA Timer 2) and platelets count obtained from records. The data collected using questionnaire, and analyzed using Statistical Package Social Science programme (Version 20). Students T test and One way ANOVA test were used to compare between means. P. value significant when ≤0.05. PT (seconds) mean and SD were 15.4±1.7, 14.6±0.8 in cases and healthy subjects respectively, P. values were 0.000 and APTT (seconds) mean and SD were 40.8±4.9, 37.1±3.3 in cases and healthy subjects respectively, P. values were 0.000. Both PT and APTT were high in SCD patient compare to control group. Mean level of platelets count (cumm) were 389±204, 281±71 in the cases and controls respectively, P. value was 0.01. Statistically there was significant deferens between cases group and control group in platelets count (cumm).increased platelet count in cases.