Abstract

Piper guineense (Uziza in Igbo) is a medicinal plant whose leaves are commonly used as spices. This study is to investigate the effects of the ethanolic leaf extracts of P.guineense on the histology of the liver, liver biomarker enzymes of paraquat-induced Thirty (30) adult male Wistar rats weighing between 160g – 200g which was randomly assigned to six Groups (A-F) of 5 rats each.  The control Group A was not induced with paraquat, while Groups B, D, E and F were induced with 20mg/kg of paraquat. Group C received 200mg/kg of the extract only. After the fourteenth day, groups E and F were withdrawn and treated with 80mg/kg and 100mg/kg of the extract, respectively, for another fourteen days; while Group D was withdrawn without treatment. The results showed that animals in all Groups(P