Abstract This study has been carried out in Radiation and Isotopes Center of Khartoum and Khartoum hospital, it, s aim was to the assessment of the effect of radiation in Blood Components from Tc-99m/MDP Bone Scintigraphy, such as the effects in WBCs, RBCs, PLT, HCT, MCV, LYM and HGB in addition to geographical distribution of cancer and highlighting the most common cancer in Sudan. The study conducted on 50 patients (50) as 76% female and 24 % male with different ages that candidate to the bone Scintigrophy with different indications except the patients who have proliferative disease in (RICK). Some data were obtained which were :geneder,weight,height, recent diagnoses, address, actual dose (admistrated doseresidual dose) and the interval time(time of the second sample collection-time of the administration dose) .The samples of blood were taken from the patients before and after the bone Scintigrophy were analyzed as complete blood counts in (RICK) and Khartoum hospital laboratories. The result shows that there were reduction effects in the counts of the blood components in the second samples. The decrement of the blood components from initial counts as 3.8% inWBCs, 3.6% in RBCs , 3.1% in HGB ,4.9% in HCT, 12.5% in PLT,10.3% in LYM and 1.5% in MCV . The result shows there are not significant or weak correlations between age and blood components like:RBCs,HGB and HCT before and after interval time of the bone scan.The weak correlations above show in the following equations as:Y=432.11X+5E+06(R 2 =9E-05) and Y=392.87X+4E+06(R 2 =9E-05) for RBCs,Y=0.0017X+12.258(R 2 =0.0002) and Y=- 0.002X+12.081(R 2 =0.0004) for HGM and Y=0.0011X+38.679(R 2 =1E-05) and Y=- 0.0175X+37.772(R 2 =0.0033)for HCT before and after interval time of the bone scan iv respectively where, y represents the blood component and x represents the age. that there were some correlations between age, interval time and the BMI versus the blood components before and after the administrated dose. Which reveal that: as the age increases as the reduction in WBC% increases following the equation of the form: where x refers to Age in year and y refers to reduction in WBC%. Also the reduction in WBC% increases as the interval time of bone scintigraphy increases and the correlation could be fitted in the following equation: where x refers to interval time of bone scintigraphy and y refers to reduction in WBC%. In addition to, the WBC count also increases as the BMI increases with a correlation could be fitted in the following equation: where x refers to BMI and y refers to WBC count.