A study on Gender and Academic performance in science was carried out in Githumu Zone with the purpose of investigating and establishing the factors influencing Gender and academic performance in the science subject in Githumu Zone. The specific objective of the study were/ to compare out the boys/girls attitude towards the study of science. To identify some cultural practices that affect the performance of learners in the science. To establish whether both sexes participate fully in the science teaching learning situation. To determine whether motivation and the resources affect gender and academic performance of science in Githumu Zone. To identify appropriate intervention measures for the problems. The method used in the investigation were qualitative, and descriptive given the nature of the research problem. Data was obtained mainly from two sources namely the pupils profile and teachers profile where a researcher formulate a questionnaires and distributed to them for assisting him to carry out the study. The population studied consisted of one hundred pupils where girls and boys sampled were equal and thirty teachers, eighteen male teachers and twelve female teachers who handles science subject in their respective schools. Teachers are all trained and obtained various qualifications and grades.