Abstract The study on the causes and effects of students’ school dropouts was carried out in Nawampiti sub-county Luuka District. The purpose of the study was to investigate the causes and effects of school dropout in schools. The research was guided by the objectives of the study which included; finding out the causes of school dropouts in Nawampiti sub-county Luuka District, finding out the effects of girls school dropouts in the community of Nawampiti sub-county. The sample size of 60 respondents was got from the population of teachers, students, political leaders and local community members. The researcher used interviews, questionnaires to collect the data. The findings revealed that; poverty, corporal punishments, chronic sickness, long distance of schools, and lengthy learning hours were the major causes of school dropouts in Luuka sub-county. High crime rates high illiteracy levels early marriages and early pregnancies were the major effects of school dropout in Nawampiti sub-county, and building of more schools, free education, compulsory education, provision of lunch in schools, reduction of learning hours were the solutions to students’ school dropouts in the community of Nawampiti sub-county. The researcher later recommended that; there is need for parental responsibility, community involvement in education, and stopping of corporal punishments were some of the recommendations made by the researcher after presenting and interpreting the data. x