ABSTRACT The study investigated the influence of motivation on job satisfaction of teachers. The objectives of the study were to find out the overall level of job satisfaction and motivation of teacher. Two research questions and three hypotheses were raised to guide the study. The study employed descriptive survey design. The respondents were selected through purposive sampling technique. A sample of 120 teachers drawn from six senior high schools in the Kassena-Nankama East Municipal was used for the study. Questionnaire was used to collect data for the study. The overall reliability coefficient obtained from the pre-test was .747. Data were analyzed using descriptive statistics such as frequencies and percentages were, means and standard deviations. Pearson product moment correlation coefficient, simple regression and Independent Sample Ttest were used to analyze the hypotheses raised. Findings revealed that overall levels of motivation and job satisfaction were high. The study established significant influence of motivation on job satisfaction of teachers. It was therefore, recommended that heads should reinforce the use of motivation and job satisfaction techniques to enable teachers give out their best to students. It was again recommended that there is a continuous need for Ghana Education Service to improve the conditions of service for teachers to gain their satisfaction for the work. Heads should consider issues that affect motivation and job satisfaction of teachers by organizing durbar every academic year during which issues bothering teachers could be welcomed, discussed and managed.