This study investigated influence of gender and self-esteem on depression among diabetic patients. One hundred and thirty (130) diabetic patients (77 with low self-esteem and 53 with high self-esteem) were used. Males and females were 65 each. Self-rating depression scale Zung (1965) and index of self-esteem Hudson (1982) were used. A 2x2 factorial design was adopted while two way ANOVA statistics was used for data analysis. Gender was found to significantly influence depression among diabetic patients F, (1,126) = 11.8 P<.01. Self-esteem was also found to significantly influence depression among diabetic patients f, (1,126) = 48.9 P<.01 level of significance. Findings were discussed in relation to literature reviewed and recommendations were also made.